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VALUES continued nonhemolytic transfusion reactions.7 Removal of leukocytes helps prevent microaggregates of white blood cells, fibrin, platelets and RBC debris that form in stored blood.7 It also helps prevent HLA alloimmunization, nonhemolytic febrile reactions, transmitting cytomegalovirus (CMV) and benefits neonates and immunocompromised patients.. FFP is most frequently transfused to replenish multiple coagulation factors in patients with documented coagulation abnormalities who are bleeding or at risk of bleeding during surgery.1 FFP is used for replacement of individual coagulation factors that are not available as concentrates (factors II, V, X and XI) and management of thrombotic thrombocytopenic purpura.1 FFP is occasionally used to replace hemostatic regulatory proteins such as antithrombin III, protein C or protein S.1 FFP also is given to patients who are bleeding while on Coumadin with vitamin K deficiency or before vitamin K reverses Coumadin’s effect..
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