Academic Research Proposal Presentation

So, you need to be ambitious, but not overly so Byung-Jun Yoon NSF CAREER Workshop UT Arlington, May 17, 2013 Proposed Research (1st Try) § Topic 1 – Probabilistic framework for comparative analysis of biological networks § Past experience with probabilistic models such as hidden Markov models (HMMs) and their variants/extensions § Already had a few publications in comparative network analysis using HMMs during the first 1.5 years at Texas A M § Topic 2 – Probabilistic network model for integrated data analysis § After joining TAMU, I got interested in joint analysis of gene expression + protein interaction data for disease diagnosis § My work at TAMU led to several publications on this topic Byung-Jun Yoon NSF CAREER Workshop UT Arlington, May 17, 2013 Proposed Research (1st Try) § Topic 3 – Application of the developed models and methods in biology and medicine § Since I am working in an interdisciplinary area, I wanted to make sure that the theoretical developments will have concrete applications in biology/medicine Byung-Jun Yoon NSF CAREER Workshop UT Arlington, May 17, 2013 Review Comments (1st Try) § First, the good part: “Overall the proposal is well written, the research is interesting, and appropriately scoped.” “ (Proposed problems) are of fundamental importance” § And now, the not so good ones: “There was discussion about how the (linear) HMM models could be extended for graphs the details were not clear” “There was concern about … lack of positioning with respect to existing work.” Byung-Jun Yoon NSF CAREER Workshop UT Arlington, May 17, 2013 Proposed Research (2nd Try) § Topic 2 – Application of the proposed framework to network alignment and network querying § Topic 3 – Develop a network synthesis model for benchmark creation performance assessment Byung-Jun Yoon NSF CAREER Workshop UT Arlington, May 17, 2013  more  specific   § Topic 4 – Identification and analysis of novel biological pathways  more  coherent  topics   § Topic 1 – D